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Formation of highly organized intracellular structure and energy metabolism in cardiac muscle cells during postnatal development of rat heart |
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| Authors: | Tiia Anmann Minna Varikmaa Natalja Timohhina Kersti Tepp Igor Shevchuk Vladimir Chekulayev Valdur Saks Tuuli Kaambre |
| Institution: | 1. Laboratory of Bioenergetics, National Institute of Chemical Physics and Biophysics, Tallinn, Estonia;2. Faculty of Science, Department of Chemistry, Tallinn University of Technology, Tallinn, Estonia;3. Laboratory of Fundamental and Applied Bioenergetics, Joseph Fourier University, Grenoble, France;4. Institute of Mathematics and Natural Sciences, Tallinn University, Tallinn, Estonia |
| Abstract: | Adult cardiomyocytes have highly organized intracellular structure and energy metabolism whose formation during postnatal development is still largely unclear. Our previous results together with the data from the literature suggest that cytoskeletal proteins, particularly βII-tubulin, are involved in the formation of complexes between mitochondria and energy consumption sites. The aim of this study was to examine the arrangement of intracellular architecture parallel to the alterations in regulation of mitochondrial respiration in rat cardiomyocytes during postnatal development, from 1 day to 6 months. |
| Keywords: | ANT adenine nucleotide translocator CK creatine kinase FFA free fatty acids ICEU intracellular energetic unit IMS intermembrane space KappmADP apparent Km of mitochondrial respiration for exogenous ADP MI mitochondrial interactosome MOM mitochondrial outer membrane MtCK mitochondrial creatine kinase OXPHOS oxidative phosphorylation PK pyruvate kinase RCI respiratory control index VDAC voltage-dependent anion channel V0 basal respiration rate Vmax maximal ADP-stimulated respiration rate |
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