Immunohistochemical demonstration of serotonin-containing nerve fibers in the cerebellum |
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| Authors: | Dr Y Takeuchi H Kimura Y Sano |
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| Institution: | (1) Department of Anatomy, Kyoto Prefectural University of Medicine, Kyoto, Japan;(2) Department of Anatomy, Shiga University of Medical Science, Otsu, Shiga, Japan;(3) Department of Anatomy, Kyoto Prefectural University of Medicine, Kawaramachi-Hirokoji, Kamikyo-ku, 602 Kyoto, Japan |
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| Abstract: | Summary The localization of serotonin (5-HT)-immunoreactive nerve fibers in the cerebellum of the rat and cat was investigated by means of the peroxidase-anti-peroxidase (PAP) method using highly specific antibodies to 5-HT.Serotonin-containing nerve fibers were distributed throughout the entire cerebellum including the deep cerebellar nuclei, while 5-HT-positive neuronal somata were not detected in the cerebellum of either species. A different pattern of 5-HT innervation was found among the three layers of the cerebellar cortex. There were also interspecific differences in the pattern of distribution of 5-HT. In the rat, the pool of 5-HT nerve fibers mainly consisted of tangential elements, which were predominant in the molecular layer, while in the cat only a few 5-HT fibers were found in the molecular layer of the cerebellar cortex; dense networks of 5-HT nerve fibers were present in the granular layer. Some differences are evident in the pattern of distribution of 5-HT fibers in cerebellar regions classified on an anatomical and functional basis.This work was supported by a grant (No. 56440022) from the Ministry of Education, Science and Culture, Japan |
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| Keywords: | Serotonin-immunoreactive nerve fibers Cerebellum Cat Rat Immunohistochemistry |
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