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Design,Synthesis and Enzymatic Inhibition of Novel Unusual Amino Acids as a Transition State Analogue of Amyloid Precursor Protein Peptide |
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| Authors: | Ghodrati Atefe Firoozpour Loghman Balalaie Saeed Hosseini Faezeh Sadat Ramezanpour Sorour Edraki Najme Mohtavinejad Naser Amanlou Massoud |
| Institution: | 1.Department of Medicinal Chemistry, Faculty of Pharmacy, Tehran University of Medical Sciences, Tehran, Iran ;2.Drug Design, Development Research Center, The Institute of Pharmaceutical Sciences (TIPS), Tehran University of Medical Sciences, Tehran, Iran ;3.Peptide Chemistry Research Center, K. N. Toosi University of Technology, Tehran, Iran ;4.Medicinal and Natural Products Chemistry Research Center, Shiraz University of Medical Sciences, Shiraz, Iran ;5.Department Radiopharmacy, Faculty of Pharmacy, Tehran University of Medical Sciences, Tehran, Iran ;6.Experimental Medicine Research Center, Tehran University of Medical Sciences, Tehran, Iran ; |
| Abstract: | International Journal of Peptide Research and Therapeutics - β-secretase 1 (BACE1) plays a pivotal role in the pathology of Alzheimer?s disease via accumulation beta amyloid in the... |
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