Pre-clinical investigation of mesenchymal stromal cell-derived extracellular vesicles: a systematic review |
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| Authors: | Faezeh Shekari Abdoreza Nazari Sara Assar Kashani Ensiyeh Hajizadeh-Saffar Rebecca Lim Hossein Baharvand |
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| Affiliation: | 1. Department of Stem Cells and Developmental Biology, Cell Science Research Center, Royan Institute for Stem Cell Biology and Technology, Academic Center for Education, Culture and Research, Tehran, Iran;2. Department of Biology, University of Science and Culture, Tehran, Iran;3. Department of Regenerative Medicine, Cell Science Research Center, Royan Institute for Stem Cell Biology and Technology, Academic Center for Education, Culture and Research, Tehran, Iran;4. Advanced Therapy Medicinal Product Technology Development Center, Royan Institute for Stem Cell Biology and Technology, Academic Center for Education, Culture and Research, Tehran, Iran;5. Department of Obstetrics and Gynecology, The Ritchie Center, Hudson Institute of Medical Research, Monash University, Clayton, Australia;1. Department of Biomedical Engineering, University of Minnesota, Minneapolis, Minnesota, USA;2. Department of Mechanical Engineering, University of Minnesota, Minneapolis, Minnesota, USA;3. Department of Laboratory Medicine and Pathology, University of Minnesota, Minneapolis, Minnesota, USA;4. Cell Therapy Clinical Laboratory, M Health Fairview, Molecular and Cellular Therapeutics, Saint Paul, Minnesota, USA;5. Dana-Farber Cancer Institute, Harvard Medical School, Boston, Massachusetts, USA;6. Center for Cell and Gene Therapy, Baylor College of Medicine, Texas Children''s Hospital, Houston, Texas, USA;1. Department of Cornea and Refractive Surgery, Narayana Nethralaya Eye Institute, Bangalore, India;2. Stem Cell Research Laboratory, GROW Laboratory, Narayana Nethralaya Foundation, Bangalore, India;3. GROW Laboratory, Narayana Nethralaya Foundation, Bangalore, India;4. Department of Vitreo-Retinal Surgery, Narayana Nethralaya Eye Institute, Bangalore, India |
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| Abstract: | The therapeutic potential of naturally secreted micro- and nanoscale extracellular vesicles (EVs) makes them attractive candidates for regenerative medicine and pharmaceutical science applications. To date, the results of numerous publications have shown the practicality of using EVs to replace mesenchymal stromal cells (MSCs) or liposomes. This article presents a systematic review of pre-clinical studies conducted over the past decade of MSC-derived EVs (MSC-EVs) used in animal models of disease. The authors searched the relevant literature in the PubMed and Scopus databases (9358 articles), and 690 articles met the inclusion criteria. The eligible articles were placed in the following disease categories: autoimmune, brain, cancer, eye, gastrointestinal, heart, inflammation/transplantation, liver, musculoskeletal, pancreas, spinal cord and peripheral nervous system, respiratory system, reproductive system, skin, urinary system and vascular-related diseases. Next, the eligible articles were assessed for the rate of publication and global distribution, methodology of EV isolation and characterization, route of MSC-EV administration, length of follow-up, source of MSCs and animal species. The current review classifies and critically discusses the technical aspects of these MSC-EV animal studies and discusses potential relationships between methodological details and the effectiveness of MSC-EVs as reported by these pre-clinical studies. |
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