Perspectives on establishing a public cord blood inventory in South Africa |
| |
| Authors: | Ignatius M Viljoen Candice Laverne Hendricks Juanita Mellet Michael S Pepper |
| |
| Institution: | 1. National Center for Cancer Immune Therapy, Department of Oncology, Copenhagen University Hospital, Herlev, Denmark;2. Department of Hematology, Rigshospitalet, Copenhagen, Denmark;1. Department of Ophthalmology, Yeouido St. Mary''s Hospital, College of Medicine, The Catholic University of Korea, Seoul, South Korea;2. Department of Ophthalmology, Byers Eye Institute, Stanford University School of Medicine, Palo Alto, California, USA;3. Department of Chemical Engineering, Stanford University, Palo Alto, California, USA;4. Department of Chemical and Biological Engineering, Gachon University, Seongnam‐si, South Korea;5. VA Palo Alto HealthCare System, Palo Alto, California, USA;1. Department of Orthopedics, Renji Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, China;2. Clinical Development, IASO Biotherapeutics Co., Ltd., Shanghai, China;1. Department of Endocrinology, First Medical Center of People''s Liberation Army General Hospital, Beijing, China;2. Department of Endocrinology, Beijing Rehabilitation Hospital of Capital Medical University, Beijing, China;3. Department of Molecular Biology, Institute of Basic Medicine, School of Life Science, People''s Liberation Army General Hospital, Beijing, China;1. Oral Medicine Research Center, Fukuoka Dental College, Fukuoka, Japan;2. Department of Oral Rehabilitation, Fukuoka Dental College, Fukuoka, Japan;3. Department of Physiological Science and Molecular Biology, Fukuoka Dental College, Fukuoka, Japan |
| |
| Abstract: | The South African population is highly diverse, both ethnically and genetically. This diversity is particularly true for the African ancestry and various mixed ancestry population groups. These groups are under-represented in national and international bone marrow and peripheral blood donor registries, making it challenging to identify HLA-matched and mismatched unrelated donors when patients from these groups require allogeneic hematopoietic stem and progenitor cell transplantation. In most high-income countries, banked cord blood (CB) units provide an attractive source of hematopoietic progenitor cells for genetically diverse populations. SA does not have a public CB inventory, leaving many patients without access to this important treatment modality. Haploidentical transplantation provides an alternative. In recent years, the use of post-transplant cyclophosphamide has significantly reduced the incidence of graft-versus-host disease after haploidentical transplantation and has improved transplantation outcomes. However, it is difficult to identify suitable haploidentical donors in SA because of family disruption and a high prevalence of HIV. Here the authors provide a brief historical overview of the ethnic and genetic diversity of the country and region. The authors provide a southern African perspective on HLA diversity, consider the allogeneic hematopoietic stem and progenitor cell transplantation landscape and explore the need to establish a public CB bank (CBB) in SA. The health policy and regulatory frameworks that will impact on a CBB in the country SA are also explored. Finally, the authors discuss several matters we believe require attention when considering the establishment of a sustainable public CBB in the South African context. |
| |
| Keywords: | |
| 本文献已被 ScienceDirect 等数据库收录！ |
|
