Human chromosome 19 carries a poliovirus receptor gene |
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Authors: | Dorothy A. Miller Orlando J. Miller Vaithllingam G. Dev Shahnaz Hashmi Ramana Tantravahi Leandro Medrano Howard Green |
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Affiliation: | Department of Human Genetics and Development College of Physicians and Surgeons Columbia University New York, N.Y. 10032 USA;Department of Biology Massachusetts Institute of Technology Cambridge, Mass. 02139 USA |
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Abstract: | The chromosome complements of human/mouse hybrid cell lines of mouse 3T3-4E and RAG parentage have been analyzed using chromosome banding methods. Three lines that were susceptible to lytic infection with poliovirus contained eleven to seventeen human chromosomes, including chromosome 19. Polio-resistant sublines of these contained no chromosome 19 and showed no other consistent change in the complement of human chromosomes. Human chromosome 19 therefore is essential for polio-sensitivity. Since polio sensitivity was correlated with receptor activity in these lines, we conclude that chromosome 19 carries the structural gene for the poliovirus receptor. Sensitivity to echo-7 and Rhino-1A viruses could not be related to the presence of a specific human chromosome. |
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