Regulation of enzyme activity by enzyme orientation: A hypothesis |
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| Authors: | H. Brockerhoff |
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| Affiliation: | Neurochemistry Department, New York State Institute for Basic Research in Mental Retardation, 1050 Forest Hill Road, Staten Island, New York 10314 USA |
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| Abstract: | In addition to substrate binding sites, many enzymes must possess supersubstrate binding sites that regulate attachment and orientation of the enzyme toward the matrix (micelle, membrane) in which the substrate molecules are embedded, the supersubstrate. |
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