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OTUB2 Promotes Cancer Metastasis via Hippo-Independent Activation of YAP and TAZ
Authors:Zhengkui Zhang  Jinjin Du  Shuai Wang  Li Shao  Ke Jin  Fang Li  Bajin Wei  Wei Ding  Peifen Fu  Hans van Dam  Aijun Wang  Jin Jin  Chen Ding  Bing Yang  Min Zheng  Xin-Hua Feng  Kun-Liang Guan  Long Zhang
Affiliation:1. MOE Laboratory of Biosystems Homeostasis and Protection and Innovation Center for Cell Signaling Network, Life Sciences Institute, Zhejiang University, Hangzhou 310058, China;2. Institutes of Biology and Medical Sciences, Soochow University, Suzhou 215006, China;3. State Key Laboratory for Diagnostic and Treatment of Infectious Diseases, The First Affiliated Hospital, School of Medicine, Zhejiang University, Collaborative Innovation Center for Diagnosis and Treatment of Infectious Disease, Hangzhou 310000, China;4. Breast Disease Center, First Affiliated Hospital of Medicine College of Zhejiang University, Hangzhou 310006, China;5. Department of Cell and Chemical Biology, Oncode Institute, Leiden University Medical Center, 2300 RC Leiden, the Netherlands;6. Department of Surgery, School of Medicine, UC Davis, Davis, CA 95817, USA;7. State Key Laboratory of Genetic Engineering and Collaborative Innovation Center for Genetics and Development, School of Life Sciences, Institute of Biomedical Sciences, Fudan University, 200433 Shanghai, China;8. Department of Pharmacology and Moores Cancer Center, University of California, San Diego, La Jolla, CA 94158, USA
Abstract:
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  • Keywords:OTUB2  SUMOylation  YAP/TAZ  deubiquitination  metastasis
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