Impaired prostaglandin release from the kidneys of salt-loaded and hypertensive rats |
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Authors: | WP Leary JG Ledingham JR Vane |
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Institution: | 1. Department of Clinical & Experimental Pharmacology, University of Natal; Nuffield Department of Medicine, University of Oxford and Department of Pharmacology, Royal College of SurgeonsEnglandEngland |
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Abstract: | Prostaglandin (PG) release by the isolated perfused kidney of the rat has been stimulated by nor-adrenaline infusion and measured by bioassay. There was no basal output of PGE2-like activity, but stimulated release reached mean concentrations of 9.1 ng/g kidney/ml perfusate in kidneys from female albino rats drinking water and 2.9 ng/g/ml in those from animals given 1.5% NaCl to drink. Kidneys from uninephrectomised animals with mock-clipped renal arteries released 7.3 ng PG/g/ml and those from rats with uninephrectomy and constricted renal arteries 3.3 ng/g/ml. |
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