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Iruka Eliminates Dysfunctional Argonaute by Selective Ubiquitination of Its Empty State
Authors:Hotaka Kobayashi  Keisuke Shoji  Kaori Kiyokawa  Lumi Negishi  Yukihide Tomari
Affiliation:1. Laboratory of RNA Function, Institute for Quantitative Biosciences, The University of Tokyo, Bunkyo-ku, Tokyo 113-0032, Japan;2. Department of Agrobiology and Bioresources, School of Agriculture, Utsunomiya University, Utsunomiya, Tochigi 321-8505, Japan;3. Central Laboratory, Institute for Quantitative Biosciences, The University of Tokyo, Bunkyo-ku, Tokyo 113-0032, Japan;4. Department of Computational Biology and Medical Sciences, Graduate School of Frontier Sciences, The University of Tokyo, Bunkyo-ku, Tokyo 113-0032, Japan
Abstract:
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  • Keywords:argonaute  microRNA  RNA silencing  ubiquitin  E3 ubiquitin ligase  Iruka  protein quality control
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