Caffeic Acid Phenethyl Ester Causes p21Cip1 Induction, Akt Signaling Reduction, and Growth Inhibition in PC-3 Human Prostate Cancer Cells |
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| Authors: | Hui-Ping Lin Shih Sheng Jiang Chih-Pin Chuu |
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| Institution: | 1Institute of Cellular and System Medicine, National Health Research Institutes, Miaoli, Taiwan;2Translational Center for Glandular Malignancies, National Health Research Institutes, Miaoli, Taiwan;3National Institute of Cancer Research, National Health Research Institutes, Miaoli, Taiwan;4Graduate Program for Aging, China Medical University, Taichung, Taiwan;Florida International University, United States of America |
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| Abstract: | Caffeic acid phenethyl ester (CAPE) treatment suppressed proliferation, colony formation, and cell cycle progression in PC-3 human prostate cancer cells. CAPE decreased protein expression of cyclin D1, cyclin E, SKP2, c-Myc, Akt1, Akt2, Akt3, total Akt, mTOR, Bcl-2, Rb, as well as phosphorylation of Rb, ERK1/2, Akt, mTOR, GSK3α, GSK3β, PDK1; but increased protein expression of KLF6 and p21Cip1. Microarray analysis indicated that pathways involved in cellular movement, cell death, proliferation, and cell cycle were affected by CAPE. Co-treatment of CAPE with chemotherapeutic drugs vinblastine, paclitaxol, and estramustine indicated synergistic suppression effect. CAPE administration may serve as a potential adjuvant therapy for prostate cancer. |
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