Regiospecific one-pot synthesis of pyrimido[4,5-d]pyrimidine derivatives in the solid state under microwave irradiations |
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Authors: | Prajapati Dipak Gohain Mukut Thakur Ashim J |
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Institution: | Department of Medicinal Chemistry, Regional Research Laboratory, Jorhat 785 006, Assam, India. dr_dprajapati@rediffmail.com |
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Abstract: | Electron rich 6-(dimethylamino)methylene]amino uracil 1, undergoes 4+2] cycloaddition reactions with various in situ generated glyoxylate imine and imine oxides 6 to provide novel pyrimido4,5-d]pyrimidine derivatives of biological significance, after elimination of dimethylamine from the (1:1) cycloadducts and oxidative aromatisation. This procedure provides a convenient method for the direct synthesis of pyrimido4,5-d]pyrimidines in excellent yields when carried out in the solid state and under microwave irradiations. |
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