A new prostaglandin E1 analogue (CL115, 574): I. Antisecretory and cytoprotectige effects in the rat |
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| Authors: | Jay E. Birnbaum Ph.D. Donald E. Wilson M.D. Ruth Partridge M.S. William Scruggs B.S. Adolph E. Sloboda Ph.D. Sandra Mouillon B.S. |
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| Affiliation: | 1. Medical Research Division, American Cyanamide Company Lederle Laboratories, Pearl River, New York, USA;2. The Department of Medicine, Section of Gastroenterology University of Illinois at the Medical Center Chicago, Illinois USA |
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| Abstract: | The effect of a new analogue of PGE1 (CL115, 574) on gastric acid secretion, mucus secretion and protection against stress and indomethacin- induced ulcers were studied in the rat. CL115, 574 was more potent than PGE1 and cimetidine in inhibiting acid secretion. CL115, 574 protected against the development of stress and indomethacin-induced ulcers prevented the indomethacin-induced decrease in hematocrit at an ED50 (3 μg/kg) far below the antisecretory ED50 (1 mg/kg). While the inhibiting acid secretion, CL115, 574 increased the volume of gastric secretion indicating a stimulation of nonparallel cell secretion by the rat stomach. In addition the compound stimulated the secretion of mucus into the gastric juice. On the basis of its potency as an inhibitor of acid secretion and these additional effects which are indicative of cytoprotective activity, CL115, 574 should be further studied as a possible anti-ulcer agent in man. |
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| Keywords: | Reprint requests to C.W.W. |
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