Modulation of Oscillatory Synchronization in an Interneuronal Network under the Influence of Tonic GABA-ergic Inhibition: a Model Study |
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| Authors: | S A Kochubey L P Savtchenko A V Sem’yanov |
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| Institution: | (1) Department of Oral and Maxillofacial Surgery, McKnight Brain Institute and College of Dentistry, University of Florida, 32610 Gainesville, Florida, USA;(2) Division of Anesthesiology, Niigata University Graduate School of Medical and Dental Sciences, 951-8510 Niigata, Japan |
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| Abstract: | The influence of a tonic GABA-ergic current on the processes of network synchronization was examined using a computer model
of the neural network with shunting GABA-ergic synapses and tonic excitation that initiated spiking. The tonic inhibitory
current was characterized by two parameters, the reversal potential and the conductance introduced. We found that tonic current
with a reversal potential more negative than the threshold for spike generation reduces the network spiking frequency and
synchronization. A monotonic decrease in the network synchronization with augmentation of the tonic current conductance was
shown. We also found that a particular range of tonic current conductance leads to a bistable character of the network dynamics.
Depending on the initial conditions of the network examined, spontaneous synchronous oscillations similar to epileptiform
activity could appear. |
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