Differential self-assembly behaviors of cyclic and linear peptides |
| |
Authors: | Choi Sung-ju Jeong Woo-jin Kang Seong-Kyun Lee Myongsoo Kim Eunhye Ryu Du Yeol Lim Yong-beom |
| |
Institution: | Translational Research Center for Protein Function Control and Department of Materials Science & Engineering, Yonsei University, Seoul, Korea. |
| |
Abstract: | Here we ask the fundamental questions about the effect of peptide topology on self-assembly. The study revealed that the self-assembling behaviors of cyclic and linear peptides are significantly different in several respects, in addition to sharing several similarities. Their clear differences included the morphological dissimilarities of the self-assembled nanostructures and their thermal stability. The similarities include their analogous critical aggregation concentration values and cytotoxicity profiles, which are in fact closely related. We believe that understanding topology-dependent self-assembly behavior of peptides is important for developing tailor-made self-assembled peptide nanostructures. |
| |
Keywords: | |
本文献已被 PubMed 等数据库收录! |
|