Prognostic value of infiltrating immune cells in clear cell renal cell carcinoma (ccRCC) |
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| Authors: | Shiyi Liu Saijiao Li Yanqing Wang Feiyan Wang Li Zhang Shu Xian Dongyong Yang Mengqin Yuan Fangfang Dai Xin Zhao Yuping Liu Yumeng Jin Zihang Zeng Omer Kamal Ahmed Mahgoub Chenliang Zhou Yanxiang Cheng |
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| Institution: | 1. Department of Obstetrics and Gynecology, Renmin Hospital of Wuhan University, Wuhan, Hubei Province, 430060 P. R. C;2. Department of Reproductive Medical Center, Renmin Hospital of Wuhan University, Wuhan, Hubei Province, 430060 P. R. C;3. Department of Tumor center, Zhongnan Hospital of Wuhan University, Wuhan, Hubei Province, 430071 P. R. C;4. Department Critical Care Medical Center, Renmin Hospital of Wuhan University, Wuhan, Hubei Province, 430060 P. R. C |
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| Abstract: | In this study, we attempted to evaluate the prognostic value of infiltrating immune/stromal cells in clear cell renal cell carcinoma (ccRCC), by using the immune scores and stromal scores based on the “Estimation of STromal and Immune cells in MAlignant Tumours using Expression data” algorithm to represent the levels of infiltrating immune cells and stromal cells. We found that the infiltrating immune cells were associated with poor prognosis of ccRCC. To assess the role of infiltrating immune cells in ccRCC cells, first, we performed differentially expressed genes analysis and functional analysis for validation. The results showed that the underlying mechanism by which infiltrating immune cells promoted cancer progression involved in regulating the nuclear division, angiogenesis, and immune response. Next, we investigated the relationship between infiltrating immune cells and mutations in ccRCC cells. We found that the infiltrating immune cells have certain effects on genetic mutations. In conclusion, infiltrating immune cells within the tumor microenvironment can be used to predict prognosis in ccRCC. |
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| Keywords: | immunotherapy mutation prognosis TCGA tumor microenvironment |
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