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Probiotics with ameliorating effects on the severity of skin inflammation in psoriasis: Evidence from experimental and clinical studies |
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| Authors: | Hadi Atabati Seyed-Alireza Esmaeili Ehsan Saburi Maedeh Akhlaghi Amir Raoofi Nima Rezaei Amir Abbas Momtazi-Borojeni |
| Affiliation: | 1. Department of Pharmacology and Physiology, Université de Montréal, Montreal, QC, Canada;2. Immunology Research Center, Bu-Ali Research Institute, Mashhad University of Medical Sciences, Mashhad, Iran Immunology Department, Faculty of Medicine, Mashhad University of Medical Sciences, Mashhad, Iran;3. Clinical Research Development Center, Imam Hasan Hospital, North Khorasan University of Medical Sciences, Bojnurd, Iran Immunogenetic and Cell Culture Department, Immunology Research Center, School of Medicine, Mashhad University of Medical Sciences, Mashhad, Iran;4. Cellular and Molecular Research Center, Sabzevar University of Medical Sciences, Sabzevar, Iran;5. Leishmaniasis Research Center, Sabzevar University of Medical Sciences, Sabzevar, Iran;6. Research Center for Immunodeficiencies, Children's Medical Center, Tehran University of Medical Sciences, Tehran, Iran;7. Halal Research Center of IRI, FDA, Tehran, Iran |
| Abstract: | Experimental and clinical studies have confirmed safety and the medical benefits of probiotics as immunomodulatory medications. Recent advances have emphasized the critical effect of gastrointestinal bacteria in the pathology of inflammatory disorders, even, outside the gut. Probiotics have shown promising results for curing skin-influencing inflammatory disorders through modulating the immune response by manipulating the gut microbiome. Psoriasis is a complex inflammatory skin disease, which exhibits a microbiome distinct from the normal skin. In the present review, we considered the impact of gastrointestinal microbiota on the psoriasis pathogenesis, and through literature survey, attempted to explore probiotic species utilized for psoriasis treatment. |
| Keywords: | bifidobacteria commensal microbiota immunomodulation Lactobacillus psoriasis |