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The posttranslational modification of HDAC4 in cell biology: Mechanisms and potential targets |
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| Authors: | Fei Hou Wei Wei Xiao Qin Jing Liang Sha Han Aizhong Han Qingsheng Kong |
| Institution: | 1. Lupus Research Institute, Affiliated Hospital of Jining Medical University, Jining Medical University, Jining, China;2. Lupus Research Institute, Affiliated Hospital of Jining Medical University, Jining Medical University, Jining, China
Collaborative Innovation Center for Birth Defect Research and Transformation of Shandong, Jining, China;3. Collaborative Innovation Center for Birth Defect Research and Transformation of Shandong, Jining, China College of Life Sciences, Qufu Normal University, Qufu, China;4. Collaborative Innovation Center for Birth Defect Research and Transformation of Shandong, Jining, China |
| Abstract: | Histone deacetylase 4 (HDAC4) is a member of the HDACs family, its expression is closely related to the cell development. The cell is an independent living entity that undergoes proliferation, differentiation, senescence, apoptosis, and pathology, and each process has a strict and complex regulatory system. With deepening of its research, the expression of HDAC4 is critical in the life process. This review focuses on the posttranslational modification of HDAC4 in cell biology, providing an important target for future disease treatment. |
| Keywords: | cell senescence cellular apoptosis and autophagy glucose metabolism HDAC4 inflammation and pathology proliferation and differentiation |