Association of C-reactive protein (CRP) rs1205 and rs2808630 variants and risk of cancer |
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| Authors: | Hai-Yan Pan Yuan-Yuan Mi Kai Xu Ze Zhang Hao Wu Wei Zhang Wei Yuan Li Shi Li-Feng Zhang Li-Jie Zhu Li Zuo |
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| Affiliation: | 1. Department of Urology, Affiliated Hospital of Jiangnan University, Wuxi, China;2. Department of Urology, The Affiliated Changzhou No. 2 People's Hospital of Nanjing Medical University, Changzhou, China;3. Department of Oncology, Taizhou People's Hospital, Taizhou, China;4. Department of Cardiology, Taizhou People's Hospital, Taizhou, China |
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| Abstract: | The correlation between rs1205, rs2808630 variants of C-reactive protein (CRP) gene and susceptibility of cancer has been assessed previously, but with conflicting results. We adopted odds ratios (ORs) with 95% confidence intervals (CIs), in silico tools and enzyme-linked immunosorbent assay (ELISA) analysis to evaluate this association. Totally, 10,614 cancer subjects and 33,294 controls were involved in the pooled analysis. When all the studies were pooled, no significant correlation was indicated between the two variants and cancer risk. However, in stratification analysis by ethnicity, we found that CRP rs1205 C>T polymorphism was associated with an elevated risk of cancer in Asians (T-allele vs. C-allele, OR = 1.20, 95% CI = 1.06–1.36, pheterogeneity = .226; TT vs. CC, OR = 1.48, 95% CI = 1.14–1.93, pheterogeneity = .089). Similar findings were observed for rs2808630 variant. In silico tools showed that lung adenocarcinoma participants with high CRP expression may have shorter overall survival time than low expression group. ELISA analysis indicated that CRP expression in prostate adenocarcinoma subjects with TT + TC genotypes was statistically higher than in those with CC genotypes. CRP rs1205 C>T and rs2808630 T>C polymorphism may be associated with cancer risk, especially for Asians. |
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| Keywords: | cancer CRP genetic variation in silico polymorphism |
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