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MicroRNAs in breast cancer: Roles,functions, and mechanism of actions |
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| Authors: | Maryam Abolghasemi Sadra Samavarchi Tehrani Tooba Yousefi Ansar Karimian Ata Mahmoodpoor Aliakbar Ghamari Farhad Jadidi-Niaragh Mehdi Yousefi Hossein Samadi Kafil Milad Bastami Mahdi Edalati Shirin Eyvazi Mohsen Naghizadeh Niloufar Targhazeh Bahman Yousefi Amin Safa Maryam Majidinia Vahid Rameshknia |
| Affiliation: | 1. Cellular and Molecular Biology Research Center, Babol University of Medical Sciences, Iran Student Research Committee, Babol University of medical sciences, Babol, Iran Maryam Abolghasemi and Sadra Samavarchi Tehrani contributed equally to this study.;2. Departmant of Clinical Biochemistry, Tehran University of Medical Sciences, Tehran, Iran Student Scientific Research Center, Tehran University of Medical Sciences, Tehran, Iran Maryam Abolghasemi and Sadra Samavarchi Tehrani contributed equally to this study.;3. Cellular and Molecular Biology Research Center, Babol University of Medical Sciences, Iran Student Research Committee, Babol University of medical sciences, Babol, Iran;4. Anesthesiology Research Team, Tabriz University of Medical Sciences, Tabriz, Iran;5. Immunology Research Center, Tabriz University of Medical Sciences, Tabriz, Iran;6. Drug Applied Research Center, Tabriz University of Medical Sciences, Tabriz, Iran;7. Department of Laboratory Sciences, Paramedical Faculty, Tabriz University of Medical Sciences, Tabriz, Iran;8. Department of Biotechnology, School of Advanced Technologies in Medicine, Shahid Beheshti University of Medical Sciences, Tehran, Iran;9. Departmant of Clinical Biochemistry, Tehran University of Medical Sciences, Tehran, Iran Student Scientific Research Center, Tehran University of Medical Sciences, Tehran, Iran;10. Student Research Committee, Babol University Of Medical Sciences, Babol, Iran;11. Molecular Medicine Research Center, Tabriz University of Medical Sciences, Tabriz, Iran;12. Institute of Research and Development, Duy Tan University, Da Nang, Vietnam;13. Solid Tumor Research Center, Urmia University of Medical Sciences, Urmia, Iran |
| Abstract: | Breast cancer is one of the most lethal malignancies in women in the world. Various factors are involved in the development and promotion of the malignancy; most of them involve changes in the expression of certain genes, such as microRNAs (miRNAs). MiRNAs can regulate signaling pathways negatively or positively, thereby affecting tumorigenesis and various aspects of cancer progression, particularly breast cancer. Besides, accumulating data demonstrated that miRNAs are a novel tool for prognosis and diagnosis of breast cancer patients. Herein, we will review the roles of these RNA molecules in several important signaling pathways, such as transforming growth factor, Wnt, Notch, nuclear factor-κ B, phosphoinositide-3-kinase/Akt, and extracellular-signal-regulated kinase/mitogen activated protein kinase signaling pathways in breast cancer. |
| Keywords: | biomarker cancer diagnosis microRNAs prognosis signal pathway |