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Role of forkhead box gene family in bone metabolism |
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| Authors: | Jinjing Huang MS Gengyang Shen PhD Hui Ren MD Zhida Zhang PhD Xiang Yu PhD Wenhua Zhao MS Qi Shang MS Jianchao Cui Peiyuan Yu MS Jiancheng Peng MS De Liang MS Zhidong Yang MS Xiaobing Jiang MD |
| Affiliation: | 1. Guangzhou University of Chinese Medicine, Guangzhou, China Lingnan Medical Research Center of Guangzhou University of Chinese Medicine, Guangzhou, China Jingjing Huang, Gengyang Shen, and Hui Ren contributed equally to this work.;2. Lingnan Medical Research Center of Guangzhou University of Chinese Medicine, Guangzhou, China Department of Spinal Surgery, The First Affiliated Hospital of Guangzhou University of Chinese Medicine, Guangzhou, China Jingjing Huang, Gengyang Shen, and Hui Ren contributed equally to this work.;3. Guangzhou University of Chinese Medicine, Guangzhou, China Lingnan Medical Research Center of Guangzhou University of Chinese Medicine, Guangzhou, China;4. Lingnan Medical Research Center of Guangzhou University of Chinese Medicine, Guangzhou, China Department of Spinal Surgery, The First Affiliated Hospital of Guangzhou University of Chinese Medicine, Guangzhou, China;5. Lingnan Medical Research Center of Guangzhou University of Chinese Medicine, Guangzhou, China |
| Abstract: | Bone metabolism is associated with many bone diseases and regulated by multiple signal pathways. Over the past three decades, the functions of a superfamily of evolutionarily conserved transcriptional regulators, known as forkhead box (Fox) family, has been demonstrated to contribute to the bone metabolism. Genetic analysis studies have demonstrated that Fox gene family participate in bone metabolism and that their expression can be regulated by multiple factors. The deregulation of Fox gene family can lead to a series of bone metabolic diseases. In this manuscript, we sketched the biology of the Foxs family, summarized its function of regulating bone metabolism and maintaining bone homeostasis to estimate its potential therapeutic effects in bone diseases, and suggested directions for future exploration in this important field. |
| Keywords: | bone metabolism forkhead box osteoblast differentiation osteogenic differentiation review |