MicroRNAs: Small molecules with a large impact on pre-eclampsia |
| |
Authors: | Maryam Hemmatzadeh Navid Shomali Yousef Yousefzadeh Hamed Mohammadi Aliyeh Ghasemzadeh Mehdi Yousefi |
| |
Affiliation: | 1. Aging Research Institute, Tabriz University of Medical Sciences, Tabriz, Iran;2. Stem Cell Research Center, Tabriz University of Medical Sciences, Tabriz, Iran;3. Department of Immunology, School of Medicine, Alborz University of Medical Sciences, Karaj, Iran;4. Department of Reproductive Biology, Faculty of Advanced Medical Sciences, Tabriz University of Medical Sciences, Tabriz, Iran |
| |
Abstract: | As critical mediators in biological processes, microRNAs (miRNAs) which are small and endogenous noncoding RNAs have been associated with disease progression, cell proliferation, and development. Pre-eclampsia (PE), a pregnancy-related disorder with no early markers or symptoms is recognized as the main reason for fetal and maternal mortality and morbidity in the initial steps or even during pregnancy, worldwide. Clinical symptoms usually appear in the third trimester of the pregnancy. Although numerous research have unraveled several aspects of placenta development abnormalities associated with abnormal trophoblastic invasion and angiogenesis modification, many questions about the PE pathogenesis remains unanswered. A large number of studies have shown the important role of miRNAs as potential biomarkers in the PE prognosis and diagnosis. Here, the latest investigations about the PE and placental miRNAs expression, as well as, the crucial role of miRNA molecules including miR-210 and miR-155 which are deregulated in patients with PE, will be argued. |
| |
Keywords: | microRNA placenta pre-eclampsia pregnancy |
|
|