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c-Myc controls the fate of neural progenitor cells during cerebral cortex development |
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| Authors: | Xiu-Li Wang Yan-Xia Ma Ren-Jie Xu Jin-Jin Ma Hong-Cheng Zhang Shi-Bin Qi Jin-Hui Xu Xu-Zhen Qin Hao-Nan Zhang Chang-Mei Liu Jian-Quan Chen Bin Li Hui-Lin Yang Saijilafu |
| Affiliation: | 1. Department of Orthopaedics, The First Affiliated Hospital of Soochow University, Orthopedic Institute, Soochow University, Suzhou, Jiangsu, China Xiu-Li Wang, Yan-Xia Ma, and Ren-Jie Xu contributed equally to this work.;2. Department of Orthopaedics, The First Affiliated Hospital of Soochow University, Orthopedic Institute, Soochow University, Suzhou, Jiangsu, China Department of Orthopaedics, Suzhou Municipal Hospital/The Affiliated Hospital of Nanjing Medical University, Suzhou, Jiangsu, China Xiu-Li Wang, Yan-Xia Ma, and Ren-Jie Xu contributed equally to this work.;3. Department of Orthopaedics, The First Affiliated Hospital of Soochow University, Orthopedic Institute, Soochow University, Suzhou, Jiangsu, China;4. State Key Laboratory of Stem Cell and Reproductive Biology, Institute of Zoology, Chinese Academy of Science, Beijing, China Savaid Medical School, University of Chinese Academy of Sciences, Beijing, China |
| Abstract: | The anatomical structure of the mammalian cerebral cortex is the essential foundation for its complex neural activity. This structure is developed by proliferation, differentiation, and migration of neural progenitor cells (NPCs), the fate of which is spatially and temporally regulated by the proper gene. This study was used in utero electroporation and found that the well-known oncogene c-Myc mainly promoted NPCs’ proliferation and their transformation into intermediate precursor cells. Furthermore, the obtained results also showed that c-Myc blocked the differentiation of NPCs to postmitotic neurons, and the expression of telomere reverse transcriptase was controlled by c-Myc in the neocortex. These findings indicated c-Myc as a key regulator of the fate of NPCs during the development of the cerebral cortex. |
| Keywords: | cerebral cortex c-Myc neural progenitor cells |