Pan-cancer analysis of iron metabolic landscape across the Cancer Genome Atlas |
| |
| Authors: | Su Zhang Wei Chang Hao Wu Yu-Han Wang Yu-Wen Gong You-Li Zhao Shan-Hui Liu Han-Zhang Wang Robert S Svatek Ronald Rodriguez Zhi-Ping Wang |
| |
| Institution: | 1. Department of Urology, Lanzhou University Second Hospital, Lanzhou, China;2. Department of Urology, Lanzhou University Second Hospital, Lanzhou, China
Su Zhang, Wei Chang, and Hao Wu contributed equally to this work.;3. Department of Urology, University of Texas Health Science Center San Antonio, San Antonio, Texas |
| |
| Abstract: | Iron is an essential metal ion in the human body and usually dysregulated in cancers. However, a comprehensive overview of the iron-related genes and their clinical relevance in cancer is lacking. In this study, we utilized the expression profiling, proteomics, and epigenetics from the Cancer Genome Atlas database to systematically characterized the alterations of iron-related genes. There were multiple iron-related genes with dysregulation across 14 cancers and some of these ectopic changes may be associated with aberrant DNA methylation. Meanwhile, a variety of genes were significantly associated with patient survival, especially in kidney renal clear cell carcinoma. Then differentially expressed genes were validated in clinical samples. Finally, we found deferoxamine and erastin could inhibit proliferation in various tumor cells and influence the expression of several iron-related genes. Overall, our study provides a comprehensive analysis of iron metabolism across cancers and highlights the potential treatment of iron targeted therapies for cancers. |
| |
| Keywords: | DNA methylation ferroptosis iron metabolism pan-cancer analysis survival |
|
|
