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Phenolic compounds of Abies nephrolepis and their NO production inhibitory activities |
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| Authors: | Li Yong-Li Wu Liang Ouyang Dan-Wei Yu Ping Xia Jia-Han Pan Yue-Xing Yang Xian-Wen Zeng Hua-Wu Cheng Xiang-Rong Jin Hui-Zi Zhang Wei-Dong |
| Affiliation: | School of Pharmacy, Shanghai Jiao Tong University, Shanghai, PR China. |
| Abstract: | Two new, i.e., 1 and 2, and 69 known phenolics were isolated from the aerial parts of Abies nephrolepis. These chemical constituents included 22 lignans, 30 flavonoids, and 19 other phenols. Their structures were determined mainly by analysis of the 1D- and 2D-NMR spectroscopic data. All the 71 isolates were evaluated for their inhibitory activities against lipopolysaccharide (LPS)-induced NO production in RAW 264.7 macrophages. Compound 1 exhibited a potent effect with an IC(50) value of 13.7 μg/ml. |
| Keywords: | Abies nephrolepis Phenolics Lignans Flavonoids Inhibitors |
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