TIC4]endomorphins, analogues of endomorphins, have significantly enhanced vasorelaxant effects in rat aorta rings |
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| Authors: | Zhao Qian-Yu Chen Qiang Feng Yun Lin Xin Wang Rui |
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| Institution: | Department of Biochemistry and Molecular Biology, School of Life Science, Lanzhou University, Peoples Republic of China. |
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| Abstract: | Tic(4)]EM1 and Tic(4)]EM2, new endomorphins (EMs) analogues, caused relaxation of rat aorta rings precontracted with phenylphrine in a concentration-dependent manner and were 240- to 370-fold more potent than EMs. This effect was inhibited by endothelium removal or by incubation with NO synthase inhibitor L-NNA or opioid receptor antagonist naloxone. The results demonstrate that Tic(4)]EMs have NO- and endothelium-dependent vasorelaxant effects which are mediated by the opioid receptor. |
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