Structure and Chromosomal Localization of the Human Homeobox Gene Prox 1 |
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Authors: | Rina D. Zinovieva Melinda K. Duncan Todd R. Johnson Rosarelis Torres Mihael H. Polymeropoulos Stanislav I. Tomarev |
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Affiliation: | aLaboratory of Molecular and Developmental Biology, National Eye Institute, National Institutes of Health, Bethesda, Maryland, 20892;bNCHGR, National Institutes of Health, Bethesda, Maryland, 20892 |
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Abstract: | The genomic organization and nucleotide sequence of the human homeobox gene Prox 1 as well as its chromosomal localization have been determined. This gene spans more than 40 kb, consists of at least 5 exons, and encodes an 83-kDa protein. It shows 89% identity with the chicken sequence at the nucleotide level in the coding region, while the human and chicken proteins are 94% identical. Among the embryonic tissues analyzed (lens, brain, lung, liver, and kidney), the human Prox 1 gene is most actively expressed in the developing lens, similar to the expression pattern of the chicken Prox 1 gene. The Prox 1 gene was mapped to human chromosome 1q32.2–q32.3. |
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