Mapping of Unconventional Myosins in Mouse and Human |
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| Authors: | Tama Hasson Joseph F. Skowron Debra J. Gilbert Karen B. Avraham William L. Perry William M. Bement Blake L. Anderson Elliott H. Sherr Zheng-Yi Chen Lloyd A. Greene David C. Ward David P. Corey Mark S. Mooseker Neal G. Copeland Nancy A. Jenkins |
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| Affiliation: | aDepartment of Biology, Yale University, New Haven, Connecticut, 06520;bDepartment of Pathology, Yale University, New Haven, Connecticut, 06520;cDepartment of Cell Biology, Yale University, New Haven, Connecticut, 06520;hDepartment of Genetics, Yale University, New Haven, Connecticut, 06520;dMammalian Genetics Laboratory, ABL–Basic Research Program, NCI–Frederick Cancer Research and Development Center, Frederick, Maryland, 21702;eDepartment of Zoology, University of Wisconsin, Madison, Wisconsin, 53706;fDepartment of Pathology, Columbia University, New York, New York, 10032;gHoward Hughes Medical Institute, Massachusetts General Hospital, Boston, Massachusetts, 02114 |
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| Abstract: | Myosins are molecular motors that move along filamentous actin. Seven classes of myosin are expressed in vertebrates: conventional myosin, or myosin-II, as well as the 6 unconventional myosin classes -I, -V, -VI, -VII, -IX, and -X. We have mapped in mouse 22 probes encompassing all known unconventional myosins and, as a result, have identified 16 potential unconventional myosin genes. These genes include 7 myosins-I, 2 myosins-V, 1 myosin-VI, 3 myosins-VII, 2 myosins-IX, and 1 myosin-X. The map location of 5 of these genes was identified in human chromosomes by fluorescencein situhybridization. |
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