Profiles of gene expression in human autoimmune disease |
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Authors: | Thomas M Aune Kevin Maas Joel Parker Jason H Moore Nancy J Olsen |
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Institution: | (1) Division of Rheumatology, Department of Medicine, Vanderbilt University School of Medicine, 37232 Nashville, TN;(2) Department of Microbiology and Immunology, Vanderbilt University School of Medicine, 37232 Nashville, TN;(3) Department of Molecular Physiology and Biophysics, Vanderbilt University School of Medicine, 37232 Nashville, TN |
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Abstract: | Human autoimmune diseases arise from complex interactions between genetic and environmental factors, result from immune attack
upon target tissues, and affect 3–5% of the population. We compared gene expression profiles (>4000 genes) in the peripheral
blood mononuclear cells of normal individuals after immunization to individuals with four different autoimmune diseases (rheumatoid
arthritis, systemic lupus erythematosus, insulin-dependent diabetes mellitus, and multiple sclerosis). All autoimmune individuals,
including unaffected first-degree relatives, share a common gene expression profile that is completely distinct from the immune
profile. Therefore, this expression pattern is not simply a recapitulation of the immune response to nonself, is not a result
of the disease process, and results, as least in part, from genetic factors. Surprisingly, these genes are clustered in chromosomal
domains suggesting there is some genomewide logic to this unique expression pattern. These data argue that that there is a
constant pattern of gene expression in autoimmunity that is independent of the specific autoimmune disease and clinical parameters
associated with any individual autoimmune disease. |
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Keywords: | Autoimmune disease genomics lymphocytes immune response human |
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