HPV转基因动物研究进展

人乳头状瘤病毒(Human papillomavirus,HPV)可以引起人宫颈癌、肛门生殖器癌、尖锐湿疣等多种良、恶性肿瘤,严重威胁人类健康。然而,由于HPV严格的嗜人类上皮组织的特性,自然状态下不感染任何实验动物,给研究HPV的感染过程、致病机理,以及开发治疗HPV感染的药物等带来了困难,因此,研究HPV的动物模型显得尤为重要。

Advances in HPV Transgenic Animals Research

Objective Human papillomaviruses (HPVs) are associated with specific benign and malignant lesions, such as cervical carcinoma, anogenital cancers, condyloma acuminata, etc. However, they are human epithelia-specific and do not infect any laboratory animals. This characteristic makes it difficult to study the infection process and pathogenisis of HPVs, and to develop anti-HPV drugs. To solve these problems, it seems important and urgent to generate animal models with HPV. Thus a review of advances in this field was made in this article.