Vaccination with carbohydrate peptide mimotopes promotes anti-tumor responses. |
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Authors: | T Kieber-Emmons P Luo J Qiu T Y Chang I O M Blaszczyk-Thurin Z Steplewski |
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Institution: | Department of Pathology and Laboratory Medicine, University of Pennsylvania, Philadelphia 19104, USA. tom@xray.med.upenn.edu |
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Abstract: | Tumor-associated carbohydrate (TAC) antigens are important targets in cancer vaccine efforts. Carbohydrates are, however, frequently poor immunogens, in that they are T-cell-independent antigens. Molecular mimicry of TAC by peptides is an alternative approach to generating anti-carbohydrate immune responses. Here we demonstrate that peptide mimotopes can elicit antibody responses that cross-react with representative human TAC antigens. Primary immunization with such a multiple antigenic peptide, along with QS-21 as adjuvant, elicits cytotoxic antibodies reactive with naturally occurring forms of TAC expressed on tumor cells, and vaccination of mice with peptide mimotopes reduced tumor growth and prolonged host survival in a murine tumor model. |
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