The micronucleus assay with mouse peripheral blood reticulocytes using acridine orange-coated slides with triethylenemelamine. |
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| Authors: | E Yamamura H Hirono M Takeuchi M Kojima S Aoki |
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| Affiliation: | Toxicology Laboratories, Yoshitomi Pharmaceutical Industries, Ltd., Fukuoka-ken, Japan. |
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| Abstract: | A micronucleus assay using mouse peripheral blood and supravital staining with acridine orange (AO) was validated by two laboratories on triethylenemelamine-treated mice. Dose- and time-dependent increases in micronucleated peripheral reticulocytes were observed. This new method can be used as an alternative to the conventional bone marrow micronucleus assay. |
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