R2D2 leads the silencing trigger to mRNA's death star |
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| Authors: | Pellino Janice L Sontheimer Erik J |
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| Institution: | Department of Biochemistry, Molecular Biology and Cell Biology, Northwestern University, Evanston, IL 60208, USA. |
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| Abstract: | During RNA interference (RNAi), Dicer generates short interfering RNAs (siRNAs), which then guide target mRNA cleavage by the RISC complex. Now, Liu et al. identify R2D2, a Dicer-associated protein that is important for siRNA incorporation into RISC, thus linking the initiation and execution phases of RNAi. |
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