Polymorphisms in the Apolipoprotein L1 gene and their effects on blood lipid and glucose levels in middle age males |
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| Authors: | Page Nigel M Olano-Martin Estibaliz Lanaway Christopher Turner Rufus Minihane Anne Marie |
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| Affiliation: | 1School of Biological Sciences, The University of Reading, RG6 6AJ Reading, UK ;2The Hugh Sinclair Unit of Nutrition, The University of Reading, RG6 6AP, UK ;3School of Food Biosciences, The University of Reading, RG6 6AP Reading, UK |
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| Abstract: | Apolipoprotein L1 in plasma is associated with high-density lipoprotein. Novel APOL1 polymorphisms are investigated along with the association of two common haplotypes (Lysl66Glu, Ile244Met, Lys271Arg) with circulating lipid and glucose levels. Although the amino acid substitutions occur in the amphipathic alpha helices region involved in lipid binding, these substitutions were found not to independently account for variability in circulating lipid and glucose levels in 149 middle age males. |
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