Detection of electrophysiological indicators of neurotoxicity in human and rat brain slices by a three-dimensional microelectrode array |
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Authors: | Köhling Rüdiger Melani Raffaella Koch Uwe Speckmann Erwin-Josef Koudelka-Hep Milena Thiébaud Pierre Balestrino Maurizio |
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Affiliation: | Institute for Physiology, Westfalische Wilhelms-University, Münster, Germany. |
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Abstract: | Electrophysiological techniques for the assessment of in vitro neurotoxicology have several advantages over other currently-used methods (for example, morphological techniques), including the ability to detect damage at a very early stage. Novel recording techniques based on microelectrode arrays are available, and could improve recording power. In this study, we investigated how a three-dimensional microelectrode array detects the electrophysiological endpoints of neurotoxicity. We conclude that electrophysiology sensitively reveals neurotoxic actions, and that three-dimensional microelectrode arrays could be proposed for use in neurotoxicology as recording tools that allow easy and sensitive multisite recording, from both rodent and human brain tissue. |
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