Linkage mapping of fifty-eight new rat microsatellite markers |
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| Authors: | Vladimir E. Sverdlov Oksana I. Dukhanina Barbara Hoebee John P. Rapp |
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| Affiliation: | (1) Department of Physiology and Molecular Medicine, Medical College of Ohio, 3035 Arlington Avenue, Toledo, Ohio 43614-5804, USA, US;(2) Laboratory of Health Effect Research, National Institute of Public Health and the Environment, Bilthoven 3720 BA, The Netherlands, NL |
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| Abstract: | Fifty-eight new anonymous simple sequence repeats (SSR) were generated and mapped to various rat chromosomes. Among them two genes (rat homologs for human cadherin-14 and mouse fibroblast growth factor-related protein) were mapped on Chromosomes (Chrs) 2 and 11 respectively. The majority of markers were generated from a small insert genomic library specific to Chr 11, 13, 14, and 15. Twenty new markers were mapped to Chr 13, which is known to contain a blood pressure quantitative trait locus (QTL). Several approaches to obtain microsatellite markers are described. The protocols and newly generated markers should be useful for ongoing rat genome project. Received: 24 April 1998 / Accepted: 23 June 1998 |
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