| 用流行性出血热单克隆抗体对我国不同地区出血热病毒株的抗原分析 |
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| 引用本文： | 陈伯权,付建林,孙月英,孟庆荣,邢峥,吴美英,刘琴芝,廖化新,周国芳,宋干,朱光奇,杨明瑞,莫尤美. 用流行性出血热单克隆抗体对我国不同地区出血热病毒株的抗原分析[J]. 病毒学报, 1986, 0(2) |
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| 作者姓名： | 陈伯权 付建林 孙月英 孟庆荣 邢峥 吴美英 刘琴芝 廖化新 周国芳 宋干 朱光奇 杨明瑞 莫尤美 |
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| 作者单位： | 中国预防医学科学院病毒学研究所(陈伯权，付建林，孟庆荣，邢峥，吴美英，刘琴芝，廖化新，周国芳，宋干)，中国医学科学院基础医学研究所(孙月英)，湖北医学院(朱光奇，杨明瑞)，湖北医学院(莫尤美) |
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| 摘 要： | 从全国17个省市自治区收集了自病人及各种动物分离到的40株流行性出血热病毒(EHFV),用出血热病毒单克隆抗体(McAb)进行抗原分析,发现大多数省市分离的EHFV株能与MA25-1 McAb起反应,但湖北、湖南分离的EHFV不与之起反应,而该McAb对EHFVA9株抗原的滴度为1/2560。实验还发现,湖北省内长江以北地区分离的EHFV毒株Q25、J173。WP43和从江南地区分离的EHFV毒株A24和HA1018在抗原性上也有明显不同。
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| 关 键 词： | 单克隆抗体 流行性出血热病毒 抗原分析 |
ANTIGENIC MONOCLONAL ANALYSIS OF EHFV STRAINS ISOLATED FROM DIFFERET AREA OF CHINA |
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| Chen Boquan Fu Jianlin Sun Yueying Men Qingrong Xing Zheng Wu Meiying Lin Qinzhi Zhou GuofangSong Gan Zhu Gungqi Yang Mengrei Mo Foumei Institute of Virology,Chinese Academy of Preventive Medicine. ANTIGENIC MONOCLONAL ANALYSIS OF EHFV STRAINS ISOLATED FROM DIFFERET AREA OF CHINA[J]. Chinese journal of virology, 1986, 0(2) |
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| Authors: | Chen Boquan Fu Jianlin Sun Yueying Men Qingrong Xing Zheng Wu Meiying Lin Qinzhi Zhou GuofangSong Gan Zhu Gungqi Yang Mengrei Mo Foumei Institute of Virology Chinese Academy of Preventive Medicine |
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| Affiliation: | Chen Boquan Fu Jianlin Sun Yueying Men Qingrong Xing Zheng Wu Meiying Lin Qinzhi Zhou GuofangSong Gan Zhu Gungqi Yang Mengrei Mo Foumei Institute of Virology,Chinese Academy of Preventive Medicine.Institute of Basic Medical Sciences,Chinese Academy of Medical Sciences,Hubei Medical College |
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| Abstract: | The antigenicity of 40 strains of EHFV isolated from patients blood and different animals in 17 provinces of China were analysed by EHFV McAb. We found that 34 strains isolated from 15 provinces reacted with EHFV McAb 25-1 in 1:20 dilution,but 6 strains isolated from Hubei and Hunan province did not.The titer of McAb 25-1 was 1:2560 when reacted with homologous EHFV A9 strain.We also found that the reaction pattern of Q25, J173, WP43 strains isolated from Hubei north of Yangtze river were remarkably different from that of EHFV A24, HA1018 which were isolated from Hubei south of Yangtze river.The implications of these findings were disussed. |
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| Keywords: | Monoclonal antibody EHFV Antigenic analysis |
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