Association analysis of SOD2 variants with methamphetamine psychosis in Japanese and Taiwanese populations |
| |
| Authors: | Kazuhiko Nakamura Chih-Ken Chen Yoshimoto Sekine Yasuhide Iwata A Anitha El-Wui Loh Nori Takei Atsuko Suzuki Masayoshi Kawai Kiyokazu Takebayashi Katsuaki Suzuki Yoshio Minabe Kenji Tsuchiya Kazuo Yamada Masaomi Iyo Norio Ozaki Toshiya Inada Nakao Iwata Mutsuo Harano Tokutaro Komiyama Mitsuhiko Yamada Ichiro Sora Hiroshi Ujike David M Ball Takeo Yoshikawa Shih-Ku Lin Norio Mori |
| |
| Institution: | (1) Department of Psychiatry and Neurology, Hamamatsu University School of Medicine, Hamamatsu 431-3192, Japan;(2) Department of Psychiatry, Chang Gung Memorial Hospital, Taipei, Taiwan;(3) Japanese Genetics Initiative for Drug Abuse, Okayama, Japan;(4) Division of Mental Health and Drug Abuse Research, National Health Research Institutes, Taipei, Taiwan;(5) Laboratory of Molecular Psychiatry, RIKEN Brain Science Institute, Saitama, Japan;(6) Department of Psychiatry, Graduate School of Medicine, Chiba University, Chiba, Japan;(7) Department of Psychiatry, Nagoya University Graduate School of Medicine, Nagoya, Japan;(8) Department of Psychiatry, Teikyo University School of Medicine Ichihara Hospital, Chiba, Japan;(9) Department of Psychiatry, Fujita Health University School of Medicine, Aichi, Japan;(10) Department of Neuropsychiatry, Kurume University School of Medicine, Kurume, Japan;(11) Division of Psychiatry, National Center Hospital for Mental, Nervous and Muscular Disorders, National Center of Neurology and Psychiatry, Tokyo, Japan;(12) Department of Psychogeriatrics, National Institute of Mental Health, National Center of Neurology and Psychiatry, Tokyo, Japan;(13) Department of Neuroscience, Division of Psychobiology, Tohoku University Graduate School of Medicine, Sendai, Japan;(14) Department of Neuropsychiatry, Okayama University Graduate School of Medicine and Dentistry, Okayama, Japan;(15) Division of Psychological Medicine, Institute of Psychiatry, University of London, London, UK;(16) Department of Psychiatry, Taipei City Psychiatric Center, Taipei, Taiwan |
| |
| Abstract: | SOD2 (superoxide dismutase 2) plays a crucial role in protecting the cells against damage caused by free radicals, by catalyzing their detoxification. On the other hand, cell damage caused by free radical generation following methamphetamine administration has been postulated as one of the possible pathophysiological mechanisms for methamphetamine psychosis. Hence, we investigated the association of SOD2 polymorphisms with the development of methamphetamine psychosis, in two independent populations of Japan and Taiwan. We recruited 116 patients with methamphetamine psychosis and 189 controls in Japan, and 135 patients with methamphetamine psychosis and 204 controls in Taiwan. The methamphetamine group was divided into two clinical subtypes: a transient type of psychosis (i.e., good prognosis) and a prolonged type of psychosis (i.e., poor prognosis), according to the course of the manifestation of psychosis. With reference to the genotypic and allelic frequencies of Ala/Val functional polymorphism in exon 2, we found significant differences between individuals with prolonged methamphetamine psychosis and control samples from Japan and Taiwan in the genotypic (P value 0.014 and 0.016, respectively) and in the allelic (P value 0.004 and 0.047, respectively) frequencies. Our results suggest that Ala/Val polymorphism of the SOD2 gene could be associated with the risk of developing methamphetamine psychosis. |
| |
| Keywords: | |
| 本文献已被 PubMed SpringerLink 等数据库收录！ |
|
