Genetic and Physical Mapping of a Gene Encoding a Methyl CpG Binding Protein, Mecp2, to the Mouse X Chromosome |
| |
Authors: | N. A. Quaderi R. R. Meehan P. H. Tate S. H. Cross A. P. Bird A. Chatterjee G. E. Herman S. D. M. Brown |
| |
Abstract: | The methyl CpG binding proteins (MeCP1 and MeCP2) are a class of proteins that bind to templates containing symmetrically methylated CpGs. Using an interspecific backcross segregating a number of X-linked markers, we have localized the Mecp2 gene in mouse to the X chromosome close to the microsatellite marker DXMit1. Detailed physical mapping utilizing an available YAC contig encompassing the DXMit1 locus has localized the Mecp2 gene to a 40-kb region between the L1cam and the Rsvp loci, indicating the probable position of a homologue on the human X chromosome. |
| |
Keywords: | |
本文献已被 ScienceDirect 等数据库收录! |
|