A mouse c-ros genomic clone: identification of a highly conserved 22-amino acid segment in the juxta-membrane domain. |
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| Authors: | L Narayana L Nagarajan |
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| Institution: | Department of Hematology, University of Texas M.D. Anderson Cancer Center, Houston 77030. |
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| Abstract: | The mouse c-ros protooncogene genomic sequences have been cloned; an analysis of the partial genomic clone revealed a high conservation of the exons encoding the juxta-membrane (JM) and the 5' most protein tyrosine kinase domains. We have identified a segment of 22 amino acids conserved between the human and mouse JM domains; this segment may have a critical role in the function of the c-ros-encoded protein tyrosine kinase receptor. |
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