Insertional mutagenesis to generate lantibiotic resistance in Lactococcus lactis |
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Authors: | Guinane Caitriona M Cotter Paul D Lawton Elaine M Hill Colin Ross R Paul |
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Institution: | Department of Microbiology, University College Cork, Cork, Ireland. |
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Abstract: | While the potential emergence of food spoilage and pathogenic bacteria with resistance to lantibiotics is a concern, the creation of derivatives of starter cultures and adjuncts that can grow in the presence of these antimicrobials may have applications in food fermentations. Here a bank of Lactococcus lactis IL1403 mutants was created and screened, and a number of novel genetic loci involved in lantibiotic resistance were identified. |
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