Hiding in plain sight: Uncovering a new function of vitamin A in redox signaling |
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Authors: | Beatrice HoyosRebeca Acin-Perez Donald A. FischmanGiovanni Manfredi Ulrich Hammerling |
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Affiliation: | a Immunology Program, Sloan-Kettering Institute for Cancer Research, 1275 York Avenue, New York, NY 10065, USAb Department of Neurology and Neurobiology, Weill-Cornell Medical School, 1300 York Avenue, New York, NY 10065, USAc Department of Cell and Developmental Biology, Weill-Cornell Medical School, 1300 York Avenue, New York, NY 10065, USA |
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Abstract: | The protein kinase Cδ signalosome modulates the generation of acetyl-Coenzyme A from glycolytic sources. This module is composed of four interlinked components: PKCδ, the signal adapter p66Shc, cytochrome c, and vitamin A. It resides in the intermembrane space of mitochondria, and is at the center of a feedback loop that senses upstream the redox balance between oxidized and reduced cytochrome c as a measure of the workload of the respiratory chain, and transmits a forward signal to the pyruvate dehydrogenase complex to adjust the flux of fuel entering the tricarboxylic acid cycle. The novel role of vitamin A as co-activator and potential electron carrier, required for redox activation of PKCδ, is discussed. This article is part of a Special Issue entitled Retinoid and Lipid Metabolism. |
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Keywords: | Vitamin A Mitochondrion Protein kinase Cδ Energy homeostasis |
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