Sterculic acid antagonizes 7-ketocholesterol-mediated inflammation and inhibits choroidal neovascularization |
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| Authors: | Jiahn-Dar HuangJuan Amaral Jung Wha LeeIgnacio M. Larrayoz Ignacio R. Rodriguez |
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| Affiliation: | a Mechanism of Retinal Diseases Section, Laboratory of Retinal Cell and Molecular Biology, National Eye Institute, National Institutes of Health, Bethesda, MD, USAb Angiogenesis Unit, Center for Biomedical Research of La Rioja (CIBIR), La Rioja, Spain |
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| Abstract: | Sterculic acid is a cyclopropene fatty acid with numerous biological activities. In this study we demonstrate that sterculic acid is a potent inhibitor of endoplasmic reticulum (ER) stress and related inflammation caused by 7-ketocholesterol (7KCh). 7KCh is a highly toxic oxysterol suspected in the pathogenesis of various age-related diseases such as atherosclerosis, Alzheimer's disease and age-related macular degeneration. Sterculic acid demonstrated to be 5-10 times more effective than other anti-inflammatory fatty acids at inhibiting 7KCh-mediated inflammatory responses in cultured cells. In vivo, sterculic acid was effective at inhibiting the formation of choroidal neovascularization (CNV) in the laser-injury rat model. Our data suggests that sterculic acid may be useful in treating CNV in certain forms of age-related macular degeneration. |
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| Keywords: | ER stress 7-ketocholesterol Inflammation Sterculic acid CHOP RPE |
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