Sister-chromatid exchange induced by X-ray of human lymphocytes and the effect of l-cysteine |
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| Authors: | Idida Abramovsky Gary Vorsanger Kurt Hirschhorn |
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| Affiliation: | Division of Medical Genetics, Department of Pediatrics, Mount Sinai School of Medicine of The City University of New York, Fifth Avenue and 100th Street, New York, N.Y. 10029, U.S.A. |
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| Abstract: | A staining technique that detects sister-chromatid exchanges (SCEs) has been used to examine the response of human lymphocyte chromosomes to various dosages of X-irradiation. The SCE frequency was markedly increased following irradiation. However, the increase was of a significantly smaller magnitude when irradiation occurred in the presence of an antimutagenic agent. Scoring SCEs may provide a useful technique for assaying the mutagenic effects of environmental carcinogens as well as the protective effects of antimutagenic agents. |
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| Keywords: | BrdU 5-bromodeoxyuridine L-cys L-cysteine SCE sister-chromatid exchanges |
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