Disorder in human myelin induced by superoxide radical: an in vitro investigation |
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Authors: | L S Chia J E Thompson M A Moscarello |
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Affiliation: | 1. Research Institute, The Hospital for Sick Children, Toronto, Ontario, Canada M5G 1X8;2. Department of Biology, University of Waterloo, Waterloo, Ontario, Canada N2L 3G1 |
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Abstract: | Potassium superoxide (KO.2), applied as a source of superoxide radical directly in vitro to white matter from young adult human brain, caused the lipid phase of the myelin to change from a crystalline (ordered) state to a liquid crystalline (disordered) state. The myelin transition temperature decreased from 65 degrees C to 37 degrees C. This alteration was accompanied by a dramatic increase in the levels of lipid peroxidation products--malondialdehyde, a conjugated diene, and ethane. These changes in human myelin, induced by direct application of O2-. radical, simulated myelin deterioration that occurs in the course of natural aging, thus, providing further substantiation for the notion that O2-. might be a major toxic agent associated with the aging process. |
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