分子模拟技术及其在苹果蠹蛾代谢杀虫剂分子机制研究中的应用进展

苹果蠹蛾是世界性重要的果树害虫,也是我国一类进境检疫性有害生物,严重威胁着我国黄土高原和环渤海湾优势苹果产区的果业生产。化学防治是当前苹果蠹蛾防治最经济有效的措施,然而频繁使用化学杀虫剂引发的抗药性问题也在世界范围内相继报道。代谢抗性是苹果蠹蛾抗性中重要的机制,苹果蠹蛾解毒酶代谢杀虫剂的分子机制是当前代谢抗性研究的重点方向。基于分子模拟的方法在相关研究中扮演着越来越重要的角色,本文综述了分子模拟涉及的主要方法及其在苹果蠹蛾代谢杀虫剂分子机制研究中的应用,并展望未来可能的研究方向。

Molecular simulation and its application progress on molecular metabolic mechanisms of insecticide in Cydia pomonella

The codling moth, Cydia pomonella(L.) (Lepidoptera: Tortricidae) is a major global pest of pome fruits, and it was considered a serious invasive species, threatening the safety of fruit production areas in Loess Plateau and Bohai Bay. The effective management of the codling moth mainly depends on chemical insecticides. However, a major problem associated with chemical control of the codling moth is the development of insecticide resistance worldwide. Among them, metabolic resistance is the main mechanism for C. pomonella resistance. To understand the metabolic mechanisms of insecticide resistance in C. pomonella, the molecular changes of detoxification enzymes were examined. Molecular simulation based methods can be important for such related research. This paper reviews the molecular simulation methods and its application in elucidating molecular metabolic mechanisms of insecticide resistance in C. pomonella. Future potential research directions using molecular simulation are put forward.