A Pilot Study on Zinc Levels in Patients with Rheumatoid Arthritis |
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| Authors: | Artur Mierzecki Dorota Strecker Krystyna Radomska |
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| Institution: | (1) Independent Laboratory of Family Physician Education, Pomeranian Medical University, ul. Rybacka 1, 70-204 Szczecin, Poland;(2) Rheumatology Outpatient Clinic in Szczecin, Szczecin, Poland;(3) Department of Paediatric Nursing, Pomeranian Medical University, ul. Zolnierska 48, 71-210 Szczecin, Poland;(4) Institute of Quantum Electronics, Military Technical Academy, ul. Kaliskiego 2, 00-908 Warsaw 49, Poland |
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| Abstract: | The aim of the study was to evaluate zinc levels in three biological compartments (serum, erythrocytes and hair) in patients
with rheumatoid arthritis (RA) as compared to healthy individuals. Zinc levels in serum, erythrocytes and hair (in 74 patients
with RA and 30 healthy individuals) were assessed by atomic absorption spectroscopy. The mean hair zinc content was significantly
lower in RA patients as compared to healthy individuals (p < 0.001). Moreover, a positive correlation was observed in the RA patient group between the erythrocyte zinc levels and the
prednisone dose (r
s = 0.48, p < 0.05), and a negative correlation was found in this population between the serum zinc levels and disease duration (r
s = −0.42, p < 0.0006). In conclusion, it seems that hair may be a useful complementary study material for evaluating “zinc status” in
rheumatoid arthritis patients. |
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