Developmental changes in the synthesis of nonhistone nuclear proteins relative to the appearance of a short nucleosomal DNA repeat length in cerebral hemisphere neurons

Fluctuations in the pattern of synthesis of nonhistone nuclear proteins were noted in cerebral hemisphere neurons during early postnatal development of the rat. Noteworthy changes included the synthesis of an acidic nuclear protein of relative molecular weight 41,000 (41 K), two chromatin-associated basic proteins (37 K and 38 K) and several high molecular weight chromatin acidic proteins. These changes in the synthesis of nonhistone nuclear proteins occur at a developmental stage when a short nucleosomal DNA repeat length has appeared in cerebral hemisphere neurons.Abbreviations used bp base pairs - DTT dithiothreitol - EDTA ethylenediaminetetraacetic acid - IF isoelectric focusing - PMSF Phenylmethylsulfonylfluoride - SDS sodium dodecyl sulphate