Consequences of renal mass reduction on amino acid and biogenic amine levels in nephrectomized mice |
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| Authors: | M Al Banchaabouchi B Marescau R D'Hooge S Engelborghs P P De Deyn |
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| Institution: | (1) Department of Neurology, Laboratory of Neurochemistry and Behaviour at the Born-Bunge Foundation, University of Antwerp, Belgium, BE;(2) Department of Neurology at Middelheim General Hospital, Antwerp, Belgium, BE |
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| Abstract: | Summary. Amino acid and biogenic amine changes were investigated in nephrectomized mice ten days postsurgery. Uremic mice exhibited
changes in amino acid concentrations in plasma, urine and brain. Particularly plasma methionine, citrulline and arginine levels
were significantly enhanced in nephrectomized mice compared to controls whereas serine was decreased. Urinary excretion of
methionine, citrulline and alanine was higher in nephrectomized mice compared to controls whereas many amino acids were increased
in brain of nephrectomized mice. Brain and urinary amino acid changes were more pronounced in the 75% than in the 50% nephrectomized
mice. Brain norepinephrine and dopamine and its metabolites 3,4-dihydroxyphenylacetic acid and homovanillic acid were significantly
increased whereas serotonin was decreased comparing the 75% nephrectomized mice to the sham-operated mice. This study demonstrates
that at very early stages of renal insufficiency, specific amino acid and biogenic amine changes occur in plasma, urine and
brain. These alterations might depend qualitatively and quantitatively on the degree of functional renal mass reduction.
Received April 5, 1999 |
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| Keywords: | : Amino acids – Biogenic amines – Renal insufficiency – Mice |
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