Characterization of a polymorphism in the coding region of the human C5a anaphylatoxin receptor |
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| Authors: | François Marceau Magdalena Bachvarova Jean Bergeron D R Bachvarov |
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| Institution: | Centre Hospitalier Universitaire de Québec, Centre de recherche du Pavillon l'H?tel-Dieu de Québec, 11 C?te-du-Palais, Québec (Québec) G1R 2J6, Canada e-mail: dimchob@rsvs.ulaval.ca Tel.: +1-418-6915590, Fax: +1-418-6915562, CA
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| Abstract: | A polymorphism was identified in the coding region of the human C5a anaphylatoxin receptor gene leading to C to T transition
at nucleotide position 450 (a silent substitution in the Ala150 codon, GCC to GCT). Its distribution was studied in a population of healthy volunteers from the Québec city region (prevalence
of 2.8%) and among patients with end-stage renal failure who had previously undergone renal graft (prevalence 1.4%, not significantly
different from that of the control group). This new marker provides a valuable tool to assess the risk for putative C5a-associated
disorders with genetic determinism.
Received: 20 November 1998 / Revised: 24 February 1999 |
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| Keywords: | Complement C5 Anaphylatoxin C5a C5a receptor G protein-coupled receptor Gene polymorphism |
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